TY  - JOUR
T1  - An Overview on Klinefelter’s: Clinical Features and Management in Pediatric Population
A1  - Asma Ayed Alanazi
A1  - Fahad Abdullah Wajdi
A1  - Mohammed Saleh Al Issa
A1  - Albandari Abdulrahman Fallatah
A1  - Abdulrazaq Oudah Shaker
A1  - Abeer Abdalaziz AlHatim
A1  - Mona Khalid Alqubali
A1  - Reem Hamoud Alshammari
A1  - Buthaynah Abdullah Alghasham
A1  - Hassan Yousef Almohammedali
A1  - Hanan Abdullah Alrashidi
A1  - Mohammed Anwar S Bawazier
JF  - International Journal of Pharmaceutical Research and Allied Sciences
JO  - Int J Pharm Res Allied Sci
SN  - 2277-3657
Y1  - 2022
VL  - 11
IS  - 1
DO  - 10.51847/GrHPjQ9TYY
SP  - 1
EP  - 5
N2  - Klinefelter syndrome is the most common sex chromosome disorder, with a prevalence of 1 in every 660 males, and despite being so prevalent, less than 30% of cases do ever get diagnosed. This is due to the very heterogeneous phenotypic presentations of the patients; failure in early identification of these patients can have dire consequences on those individuals’ overall health and life quality as it is a major cause of primary hypogonadism and subsequent infertility, in addition to the increased risk of neoplasms and a plethora of other systemic conditions. Our objective was to look into the literature concerning Klinefelter’s: clinical features and management in the pediatric population. PubMed database was used for articles selection, from where the papers were obtained and reviewed. The clinical presentation of Klinefelter syndrome patients can vary dramatically based on the age and severity of the disease. Most cases have near-normal phenotypes during infancy except for extreme phenotypes that could present with micro-pen undescended testis. As the child grows and reaches puberty detection rate increases as signs of normal puberty such as virilization and increase in muscle mass are usually deficient or incomplete. Most cases only picked up during adulthood who presents complaining of infertility. The treatment approach consists of testosterone therapy, assisted fertility, and early detection and treatment of associated complications. 
UR  - https://ijpras.com/article/an-overview-on-klinefelters-clinical-features-and-management-in-pediatric-population-rdkfecrgtqqqwz5
ER  -