%0 Journal Article
%T Antiestrogenic Potential of Turmeric Rhizomes Extract to Decrease Weight and Uterine Diameters on Rats
%A Indriyani Hendri Busman
%A Rika Mutiara Gemiralda
%J International Journal of Pharmaceutical Research and Allied Sciences
%@ 2277-3657
%D 2021
%V 10
%N 1
%R 10.51847/87VzQK5
%P 88-92
%X Turmeric (Curcuma longa L.) as an antiestrogenic can inhibit the hypothalamic-pituitary axis so that estrogen secretion is disturbed and affects the weight and diameter of the uterus. This study was conducted to examine the effect of turmeric extract (Curcuma longa L.) on weight and uterine diameters of female white rats (Rattus norvegicus) Sprague Dawley strain. Twenty-eight female rats were divided into four groups. Group C as a control (given H2O), T1 (given 250mg/ Kg BW turmeric extract + 1ml H2O), T2 (given 500mg/ Kg BW turmeric extract + 1ml H2O), and T4 (given 1000mg/ Kg BW turmeric extract + 1ml H2O). Turmeric extract was given daily for five days. The result showed that giving 250mg/Kg BW and 1000mg/Kg BW of turmeric extract significantly decrease weight and uterine diameters of female rats. In the conclusion, turmeric extract can decrease weight and uterine diameters and showing antiestrogenic potential in female rats.  
%U https://ijpras.com/article/antiestrogenic-potential-of-turmeric-rhizomes-extract-to-decrease-weight-and-uterine-diameters-on-rats