%0 Journal Article
%T Determination of Stability Constants of Ibandronate Complexes with Ca(II), Mg(II) and Sr(II)
%J International Journal of Pharmaceutical Research and Allied Sciences
%@ 2277-3657
%D 2019
%V 8
%N 2
%P 111-117
%X In this study, a potentiometric titration method by Calvin-Bjerrum and Irwing-Rosotti was used to investigate binary complexes of ibandronate sodium, a nitrogen-containing bisphosphonate, with Ca(II), Mg(II) and Sr(II). Dissociation constants (pKa) of ibandronate sodium were measured and the stability constants of the complexes formed in aqueous solutions at 22 oC (I = 0.11 M NaClO4) were determined. The stoichiometry of ibandronate sodium/metal complexes was found as 1/1 for each metal ion.
%U https://ijpras.com/article/determination-of-stability-constants-of-ibandronate-complexes-with-caii-mgii-and-srii