TY  - JOUR
T1  - Determination of Stability Constants of Ibandronate Complexes with Ca(II), Mg(II) and Sr(II)
JF  - International Journal of Pharmaceutical Research and Allied Sciences
JO  - Int J Pharm Res Allied Sci
SN  - 2277-3657
Y1  - 2019
VL  - 8
IS  - 2
SP  - 111
EP  - 117
N2  - In this study, a potentiometric titration method by Calvin-Bjerrum and Irwing-Rosotti was used to investigate binary complexes of ibandronate sodium, a nitrogen-containing bisphosphonate, with Ca(II), Mg(II) and Sr(II). Dissociation constants (pKa) of ibandronate sodium were measured and the stability constants of the complexes formed in aqueous solutions at 22 oC (I = 0.11 M NaClO4) were determined. The stoichiometry of ibandronate sodium/metal complexes was found as 1/1 for each metal ion.
UR  - https://ijpras.com/article/determination-of-stability-constants-of-ibandronate-complexes-with-caii-mgii-and-srii
ER  -