TY  - JOUR
T1  - Effect of aqueous Salvia officinalis extract on Aluminum chloride-induced neurotoxicity in female rats
A1  - Amina Boussadia
A1  - Omar Kharoubi
A1  - Zakia Lahouel
A1  - Abderrezzak Benglia
A1  - Abdelkader Aoues
JF  - International Journal of Pharmaceutical Research and Allied Sciences
JO  - Int J Pharm Res Allied Sci
SN  - 2277-3657
Y1  - 2020
VL  - 9
IS  - 2
SP  - 139
EP  - 150
N2  - The neurotoxicity of Aluminum has been discovered in several experiments. It is a neurotoxic element involved in the etiology of some neurodegenerative diseases. Hence, the present study was designed to evaluate the neuroprotective effect of Salvia officinalis aqueous leaf extract (SAE) on the behavioral, histological, and biochemical alterations caused by Aluminum chloride in female Wistar rats. Chronic aluminum chloride (AlCl3) exposure developed behavioral deficits by decreasing locomotor activity and caused a significant reduction of spontaneous alternation. Besides, AlCl3 exposure showed a significant decrease in Acetylcholinesterase activity (-54.49%), Catalase activity (-42.48%), and a significant increase in the mean concentration of Malondialdehyde (MDA) compared to control group. Histological alterations were observed in the brain of aluminum chloride exposed group, which explains the neurodegenerative effect of aluminum on rat brain histology. SAE treatment improved behavioral and histological changes in AlCl3-induced rats, attenuated biochemical alteration by recording an increase in Acetylcholinesterase activity at 73.68% and enhanced catalase activity by 62.7%, as well as a decrease in the MDA level of -86.81% compared to the AlCl3 group. The current study demonstrates that Salvia officinalis can be administered as a food additive to protect against the neurotoxicity of AlCl3 and to ameliorate behavioral and oxidative status.
UR  - https://ijpras.com/article/effect-of-aqueous-salvia-officinalis-extract-on-aluminum-chloride-induced-neurotoxicity-in-female-rats
ER  -