TY - JOUR T1 - Evaluation of Haematological Alterations in Intraperitoneal and Oral Rotenone Induced Parkinson’s Disease Wistar Rat A1 - Suchitra Kavuri A1 - Senthilkumar Sivanesan JF - International Journal of Pharmaceutical Research and Allied Sciences JO - Int J Pharm Res Allied Sci SN - 2277-3657 Y1 - 2019 VL - 8 IS - 2 SP - 143 EP - 149 N2 - In the present work, we examined intraperitoneal (3 and 6 mg/kg body weight [bw]; Rot-3-ip and Rot-6-ip, respectively) and oral (50 and 100 mg/kg bw; Rot-50-po and Rot-100-po, respectively) rotenone induced PD modeled Wistar rats to evaluate changes in various haematological parameters. While Rot-3-ip for 21 days and Rot-50-po for 28 days caused major Parkinson’s disease (PD)-related alterations, Lewy bodies were only detected in Rot-3-ip rats. The Rot-6-ip and Rot-100-po treatments caused lethal toxicity. The ip and po rotenone doses significantly (p < 0.05) and dose dependently altered several haematological variables (haemoglobin [Hb], red blood cells [RBCs], white blood cells [WBCs] and packed cell volume [PCV]). UR - https://ijpras.com/article/evaluation-of-haematological-alterations-in-intraperitoneal-and-oral-rotenone-induced-parkinsons-disease-wistar-rat ER -