TY  - JOUR
T1  -  Biologically Active Complexes Based on Natural Raw Materials: Composition and Prospects for Use
A1  - Poznyakovsky Valeriy Mikhailovich
A1  - Boisjon Tokhiriyon
A1  - Pliska Olga Vladimirovna
A1  - Ustinova Yulia Vladislavovna
A1  - Chelnakova Nina Grigorevna
JF  - International Journal of Pharmaceutical Research and Allied Sciences
JO  - Int J Pharm Res Allied Sci
SN  - 2277-3657
Y1  - 2023
VL  - 12
IS  - 3
DO  - 10.51847/zgAyWaTFRK
SP  - 88
EP  - 93
N2  - In order to improve the absorption of biologically active chemicals and compounds with limited bioavailability, the present study examines the feasibility of mixing partly soluble arabinogalactan polysaccharides with chitosan polysaccharides. Chitosan succinate, succinic anhydrate, and arabinogalactan with covalently unbound dihydro quercitin, with weight percentages of 3.0-5.0, 2.0-4.0, 15.0-20.0, and 3.0-5.0, respectively, are all components of the physiologically active biopolymer matrix. They act as vehicles for the precise delivery of medicinal and diagnostic substances to specific cells, such as hepatocytes (parenchymal liver cells), such as enzymes, nucleic acids, vitamins, and hormones. Arabinogalactan from Siberian larch (Larix sibirica) was shown to have strong membranotropic activity in the research. Because arabinogalactan creates a binding complex with the drug being administered and engages with the cell's asialoglycoprotein receptor, it can be utilized to improve the absorption of other active components with limited bioavailability through the digestive tract. The paper also examines the effectiveness of arabinogalactan to improve the technological and functional properties of PSE-like broiler meat. The addition of arabinogalactan to sausage filling in an amount of 0.5% of the total raw materials increased the moisture-binding capacity by 5% while reducing losses during heat treatment by 6%. We can also note better peroxide and acid values during storage resulting in oxidative process inhibition and prevention of product spoilage.

The possibilities of developing a new gel complex polymer based on the polysaccharide matrix as well as its use in health-saving technologies have been considered. 
UR  - https://ijpras.com/article/nbspbiologically-active-complexes-based-on-natural-raw-materials-composition-and-prospects-for-us-enol6bu72ydfwpp
ER  -