TY - JOUR T1 - The Chemical Investigation of Four Balanophora Species and Cytotoxicity with Inhibition of NO Production A1 - Nguyen Thanh Tung A1 - Nguyen Viet Than A1 - Nguyen Quang Hung A1 - Ain Raal JF - International Journal of Pharmaceutical Research and Allied Sciences JO - Int J Pharm Res Allied Sci SN - 2277-3657 Y1 - 2021 VL - 10 IS - 2 DO - 10.51847/rR1GviyLsl SP - 1 EP - 9 N2 - The phytochemistry and biological activity of four rare Balanophora species (B. subcupularis P.C. Tam (BS), B. tobiracola Makino (BT), B. fungosa var. globosa (Jungh.) B.Hansen (BFG), and B. fungosa subsp. indica (Arn.) B.Hansen (BFI)) growing in Vietnam have been studied. The six pentacyclic triterpenoids including β-amyrin, β-amyrone, lupenone, lupeol, β-amyrin acetate, and lupeol acetate could be identified in all GC-MS chromatograms of four species but very different area percentage. The chemical investigation of B. subcupularis and B. tobiracola led to the isolation of coniferyl aldehyde, gallic acid, cinnamic acid, and caffeic acid. Gallic acid and coniferyl aldehyde were isolated from B. subcupularis for the first time, Among isolated compounds, coniferyl aldehyde showed moderate cytotoxicity activity at cancer cell lines MCF-7, A549, Hep3B, and PC3 at the concentration of 100 µg/ml (CS% = 24.05 – 46.61%). Besides, this compound also significantly inhibited NO production (I% = 101.96 and 114.29 at two respectively concentrations of 30 µg/ml and 100 µg/ml). UR - https://ijpras.com/article/the-chemical-investigation-of-four-balanophora-species-and-cytotoxicity-with-inhibition-of-no-produc-hrvjrdexilbrznj ER -