TY  - JOUR
T1  - Antidiabetic effect of Punica Granatum Peel Extract, Spilanthes Paniculata Flower Extract and Selenium in Streptozotocin Induced Diabetes
JF  - International Journal of Pharmaceutical Research and Allied Sciences
JO  - Int J Pharm Res Allied Sci
SN  - 2277-3657
Y1  - 2015
VL  - 4
IS  - 2
SP  - 112
EP  - 118
N2  - The present study was aimed to evaluate the antidiabetic potential of combination of punica granatum peel extract, spilanthes paniculata flower extract and selenium in streptozotocin (STZ) induced diabetes in mice. Group A was used as control and Group B was used as diabetic control (STZ, 40mg/kg for 3 days, i.p.). A placebo was given to both the group orally. Metformin (120mg/kg) was given intraperitoneally as standard drug to Group C. Ethanolic peel extract of punica granatum (EPP 600mg/kg, p.o.) was administered to group D, (EPP) in combination with ethyl acetate extract of spilanthes paniculata flower (EAS) was administered to group E (EPP 300mg/kg, p.o. + EAS 200mg/kg, p.o.), Sodium selenite was given with combination of herbal extract (EPP 300 mg/kg, p.o.+ EAS 200mg/kg, p.o. + Se 0.3mg/kg, i.p.) to group F. STZ was given in multiple low doses of 40mg/kg, i.p. for 3 consecutive days & hyperglycemia was observed on 7th day. Blood glucose was determined on 0th, 7th, 14th, and 21st day. Diabetic mice in all group showed significant (P
UR  - https://ijpras.com/article/antidiabetic-effect-of-punica-granatum-peel-extract-spilanthes-paniculata-flower-extract-and-selenium-in-streptozotocin-induced-diabetes
ER  -