Antiulcerogenic Activity of Caesalpinia Pulcherrima Leaves
Peptic ulcer disease (PUD) is one of the leading diseases throughout the world that requires a rational therapy for better therapeutic effect. Use of conventional drug regimen used as an antiulcer like; proton pump inhibitor, H2 antagonist shown incidence of relapses, side effect, and drug interaction. The use of herbal drug is the choice of drug for all kind of diseases, especially in peptic ulcer disease. This study was undertaken to evaluate the potential of anti-ulcerogenic activity of leaves of Caesalpinia pulcherrima in ethanolic extract. The ethanolic extract of Caesalpinia pulcherrima was found to be significant at 500 mg/kg b.wt. in aspirin induced ulcer model in rat. The parameter evaluated as ulcer index, gastric volume, pH, content of tissue glutathione, acidic volume, total protein was recorded. In aspirin induced model, a decrease in ulcer index, total acidity, total volume of gastric secretion and increase in total protein, glutathione content and pH of gastric secretion when compared with toxic was observed. It is concluded that the ethanolic extract of Caesalpinia pulcherrima was found to be significant at dose of 500mg/kg as an anti-ulcerogenic.