Comparison of the Effect of Ovariectomy and Ovariohysterctomy on Some Immunity Responses in Dogs


Abstract

Ovariohysterectomy and ovariectomy are commonly used to control the pet population and the health and behavioral benefits of dogs and cats. The aim of this study was to evaluate the inherent and humoral immune factors following ovariohysterectomy and ovariectomy surgery in female dogs. In this study, 18 female dogs were used. After anesthesia, animals received one of the following three treatments randomly: 1- laparotomy (control group) 2- ovariohysterectomy 3- ovariectomy. The intrinsic and humoral immunity at baseline, 7, 14, 30 and 60 days after surgery were evaluated. In the control group, up to the 7th day of the study, serum myeloperoxidase and bactericidal activity increased, lysozyme and complement activity decreased, and constant antitrypsin activity was observed. Ovariohysterectomy and / or ovariectomy have led to a change in the pattern of variation in the experimental group. Except for antitrypsin, the change in the other factors compared to the control group was milder or less; there was a significant difference in the activity of the complement, myeloperoxidase and lysozyme activity compared to the control group. The total amount of immunoglobulins in the blood, the level of anti-salmonella antigen and anti-sheep red blood cell antibody in the experimental groups was decreased in comparison to the control on day 7. Although ovariohysterectomy and ovariectomy resulted in a weaker immune response than the control group, there was no significant difference between the two groups.



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