Formulation and Evaluation of Glipizide Buccal Adhesive Tablets Using Natural Edible Mucoadhesives


In the present work,the mucodhesive tablets of Glipizide were prepared by using different concentrations of Cashewnut tree gum,Aegle marmelos gum,Moringa Oleifera as a binder.The four tablet formulation was prepared by using drug and with polymer like cashew nut tree gum,Aegle marmelos gum,Moringa Oleifers gum ratio 1:0.5,1:0.75,1:1,1:1.25 by direct compression technique. Tablets were subjected to evaluation of uniformity of weight, hardness, friability, drug content uniformity, swelling studies, surface pH study, Ex-vivo mucoadhesive time, Ex-vivo Bioadhesive strength and Invivo drug release study. Drug polymer interaction were evaluated by Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry. All the formulations hardness,weight variation,friability and drug content values were found to be within pharmacopoeia limits. As the amount of polymer in the tablets increase,the drug release rate decreases,where as swelling index and mucoadhesive strength increases.The in vitro drug release of all formulations exhibits complete release of Glipizide with zero order release kinetics and followed by Higuchi mechanism.From the study it can be concluded that cashew nut tree gum,Aegle marmelos gum,Moringa Oleifera gum used as a binding agent in mucoadhesive buccal tablet.