Aljadani N.A., Elnaggar M.H.R., Assaggaff A.I.

Abstract

Pollutants in the environment and exposure to them lead to medical ailments around the world. The present study aimed to evaluate the protective effect of evening primrose oil and fish oil against fenitrothion pesticide-induced toxicity in rats. Male Wistar rats weighing 150-220 g, were randomly distributed into seven groups, the first served as control. The second group received fenitrothion, the third and fourth groups were supplemented with fish oil and evening primrose oil, respectively. Rats of group five were exposed to fish oil and fenitrothion. The sixth group was exposed to evening primrose oil and fenitrothion. Rats of the seventh group were exposed to fish oil and evening primrose oil and fenitrothion. The results showed that the activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and the levels of bilirubin (BIL), total protein (TP), albumin (ALB), glucose (GLU), cholesterol (CHOL), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), very low-density lipoproteins cholesterol (VLDL-c), and superoxide dismutase (SOD) were noticeably increased in rats administered fenitrothion. However, the level of serum high-density lipoprotein cholesterol (HDL-c) and glutathione (GSH) were markedly decreased. It was found that fish oil and evening primrose oil decreased the physiological unsettling influences initiated by fenitrothion. Moreover, the antioxidant properties of these oils supported the bioactive roles of its defensive impacts on fenitrothion toxicity. Finally, the present findings suggest that these oils may be utilized as preventive components against the toxicity of fenitrothion because of their antioxidant properties.