Pear is a gently sweet fruit, arich source of several nutrientsincludingfiber, sugar, vitamin C molecules, and potassium. This article reports the history, consumption, Types, health benefits, and diseases of various fruit juices. Carbohydrates, Fructose, sucrose, vitamin C, fibers, vitamins, and minerals are prime constituents present in almost all juices. The nutrition composition, manufacturing technique, processing steps, specification, stability data, contamination, and related details of pear juice are discussed in this review. The pharmacological and functional applications of pear juice like Anti-diabetic, Anti-hyperlipidemic, Anti-inflammatory, and Cardio-protective, etc. are covered with their mechanism of action. The marketed preparation and patents are also highlighted. Moreover, the analytical estimation of active constituents by spectroscopy and chromatography [like UV, HPLC, UPLC, and mass spectroscopy] isexplained in this article. The physic-chemical properties, synthesis, chemistry, biological study, pharmacokinetics, and pharmacodynamics of fructose, sucrose, and ascorbic acid, which are chief phytoconstituents in pear juice, are explained in the present article. This review suggests therapeutic pharmacological andanalytical techniques available for estimating sucrose, fructose, and ascorbic acid analytically and bioanalytically. This will contribute in creating a straightforward and verified procedure that complies with green chemistry.