Tamerlan Tulegenovich Zakaev , Medina Vakhaevna Bakrieva , Rabiyat Tazhutdinovna Alkhazova , Diana Borisovna Girkina , Anzhela Yunusovna Chagarova , Angelina Andreevna Polyanskaya

Abstract

According to statistics from the World Health Organization (WHO), from 9 to 45% of people are susceptible to diseases of the musculoskeletal system. In addition, about 3% of people can be classified as disabled due to their condition of bones and joints, and almost every one of this 3% will experience severe pain. To eliminate pain, doctors prescribe nonsteroidal anti-inflammatory drugs (NSAIDs) to these people. Within the framework of this article, the possibility of using NSAIDs in chronic inflammatory rheumatic pathologies was considered, and their effect on the human body was also considered. In a study of patients with severe psoriatic arthritis, it was found that prevention with methotrexate led to the least number of cases of cardiovascular diseases in comparison with other methods of prevention, including traditional treatment, phototherapy, and climatotherapy. It has also been suggested that the effect of inhibitors is a defense against tumor necrosis. The method of prevention of patients with severe forms of psoriatic arthritis can greatly affect the reduction in the number of cardiovascular diseases, as a result, local studies are needed to more accurately assess the cardiovascular safety and effectiveness of systemic therapy.