Drug Release of Bacterial Cellulose as Antibacterial Nano Wound ‎Dressing

Bacterial cellulose (BC) is a natural polymer that can be utilized for many ‎applications. Because of its renewable nature, good biocompatibility and excellent ‎physical features of bacterial cellulose, it can be utilized in pharmaceutical, ‎biomedical fields, and nanotechnology applications. In this study, we prepared ‎antibiotic bacterial cellulose loaded with tetracycline hydrochloride and gentamicin, ‎and its drug release, as well as antibacterial activity, were evaluated separately. The ‎structure and morphology of the loaded bacterial cellulose were determined by ‎scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy ‎‎(FTIR). AATCC100 test was used for antibacterial properties against Escherichia coli ‎and Staphylococcus aureus. Ultraviolet spectrophotometry device was used to detect ‎absorption and release process of mentioned antibacterial cellulose. By these unique ‎specifications of bacterial cellulose layer loaded with tetracycline hydrochloride and ‎gentamicin, we found that they may successfully serve as a wound dressing and other ‎medical biomaterials‎‎‎.