Background: Metabolic syndrome includes atherogenic dyslipidemia, obesity, hypertension, hyperglycemia, and insulin resistance. This complex of metabolic abnormalities is a risk factor for DM2, stroke, adverse cardiac events, and hepatic necrosis. In the last few years, studies showed a significant high prevalence of this syndrome among Saudi males. Central visceral adiposity is thought to be the primary trigger of most pathogenic events involved in the advent of the syndrome. Objectives: In this paper, our aim is to discuss metabolic syndrome, its definitions, pathophysiology, diagnosis, screening, and the management done for such patients in general with special focus to primary healthcare. Methodology: PubMed database was used for articles selection. Conclusion: The syndrome is linked with significant impacts on the patient health; as a result, the health care providers shall be alarmed on how to screen, diagnose and manage such disease. Prevention of childhood obesity is critical through screening and early diagnosis to save major burden and prevent future complications. Thus, nowadays, the new trend is towards incorporating screening of this syndrome in primary health care centers.