This cross-sectional research was carried out in the College of Medicine at the University of Taif, Kingdom of Saudi Arabia. It included a random sample of medical students in 4th, 5th and 6th years (males and females). Data were collected using a semi-structured, self-administered questionnaire, including comprehensive, anonymous demographic and socioeconomic data, lifestyle factors, health related quality of life, social support, student’s academic motivation, the past year grade point average (GPA). The study included 261 students. The age ranged between 21 and 27 years (22.8±1.1 years). Males represented 55.9% of the participants. Moreover, non-smokers, membership in charity association, having higher score of psychological domain of quality of life, and higher learning strategies score were significantly associated with grade point average (GPA) score and they are responsible for 21.5% variability of the score. From the results it could be concluded that Academic performance of senior medical students in Taif University, manifested by GPA score is influenced by many factors (multi-factorial) that are responsible for only 21.5% of variability in grade point average (GPA).
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