Formulation and Optimization of Rifampicin and Quercetin Laden Liquisolid Compact: In-Vitro and In-Vivo Study
Abstract
The major objective of this study is to create rifampicin and quercetin-containing liquisolid compacts with improved gastrointestinal absorption and dissolving properties. Propylene glycol, PEG 200, and Tween 20 were chosen as ideal non-volatile liquid carriers to create the required formulations because of their increased drug solubility. In an attempt to create a free-flowing, compressible powder, the liquisolid formulations were then combined with a carrier and coating material. In order to create liquisolid powders with good flow qualities, Avicel pH-102, Aeroperl 200, and Aerosil 200 demonstrated good liquid retention potential values, demonstrating their efficiency as solid carrier and coating materials in the creation of liquisolid compacts. The medication and carrier had no discernible interaction, according to FT-IR spectra. The DSC and PXRD experiments proved that the crystalline form of the medication was absent from the liquisolid powders. Furthermore, the improved drug dissolving performance in liquisolid systems revealed that the drug had changed into a molecular or amorphous state. In-vivo rat pharmacokinetic investigations revealed the ability of non-volatile liquid carriers of liquisolid systems to enhance drug absorption from formulation and enhance the gastrointestinal absorption and dissolving rate of rifampicin and quercetin.
