Background : CKD is prevalent in most parts of the world. CKD can be prevented and controlled by controlling its underline causes. Therefore, the objective of the present study was to assess the knowledge and perception toward CKD prevention and control in Saudi Arabia. Methodology: This was a prospective descriptive study which included 783 apparently healthy Saudi volunteers, their ages ranged from 20 to 65 years with the mean age of 37 years. A purposeful questionnaire was designed and used for obtaining data about the CKD. Results: Out of 783 contributors, 232(29.6%) were males and 551(70.4%) were females, giving males' females' ratio of 1.00: 2.37. On asking the participants the question of “whether continuous doing renal function test for at risk individuals can reduce the burden of CKD,” about 85% agreed, and 15% disagreed. On asking the participants the question of “whether controlling HTN can reduce the burden of CKD,” about 30.6% agreed and 69.3% disagreed. On asking the participants the question of “whether controlling DM can reduce the burden of CKD,” about 54.7% agreed and 45.3% disagreed. Conclusion : There was a relatively high positive attitude and knowledge toward CKD prevention and control among the educated Saudi population. Further efforts to promote health knowledge, particularly among less educated section has been needed in order to increase the chances of CKD prevention and control.