Oral diseases qualify as major public health problems owing to their higher incidence and substantial social impact. Many systemic diseases are related to oral conditions and affect general health. Dental care for chronically ill and non-ambulatory, debilitated patients has an impact on clinical outcomes and well-being. Poor oral care results in infections and affects the quality of life. Hence, oral healthcare of these patients is the nursing staff's significant responsibility. The aim of the study was to evaluate the attitudes and practices among nurses concerning the oral health care of debilitated patients in hospitals of Krishna Institute of Medical Sciences. A specially designed questionnaire was used consisting of 15 questions to assess the knowledge and attitude among nurses toward oral health care of debilitated patients. Data were collected among 180 nurses using a self-administered questionnaire. Data were analyzed using SPSS software. The results of the study stated that the majority of the nursing staff strongly agreed that the health of the teeth and gums affects the general health of the patients. Also, nurses feel there is a need to receive regular training on oral health management for debilitated patients. To conclude the attitude of nursing staff, towards oral healthcare of debilitated patients care is positive. However, respondents opine that a clinical training module at a dental institute would be more beneficial and effective delivery of oral health care.