Neem Fruit Mucilage Impact on Acyclovir Release at Different Intervals : A Central Composite Design Screening

The drive of this exploration is to look into the supportive mucoadhesive assets of neem (Azadirachta indica) fruit mucilage by incorporating it into mucoadhesive microspheres by taking Acyclovir (ACR) as a model drug. Nine interpretations of mucoadhesive microspheres were made with Methocel 934P and varying proportions of Neem fruit mucilage (NFM). A central composite design with design expert software to check the impact of independent variables (neem mucilage and methocel 934 P levels) on ACR release at 3h, 6h, and 10h as a response. As part of congeniality studies, the microspheres were examined for ACR content and its liberation. The research discovered that NFM can be used as an additive mucoadhesive polymer with Methocel 934 P and ACR can be systematically released in a controlled manner. The formulated microspheres were found to have good entrapment efficacy, mucoadhesion, drug contents, and other constraints assessed. NFM is capable of enhancing the mucoadhesion in combination with methocel 934 P and ACR can be retained in the stomach with its sustained release as mucoadhesive microspheres.