Passive Immunotherapeutic Approaches for Treating Covid-19: A Comprehensive Review
During the recent pandemic, COVID-19 (SARS-CoV-2) was the causative agent of the severe acute respiratory syndrome, which resulted in thousands of cases and high mortality rates in all the countries affected. This review focuses on immune-therapy techniques for treating COVID-19. The distinctive immunotherapeutic techniques are interferon administration, convalescent plasma, intravenous immunoglobulin, monoclonal antibodies, cellular treatments, and immunomodulatory drugs. Aside from antivirals, immunotherapy is recommended because of the immunity against the antigen in the infected patient and interferon activation is inhibited by the virus to avoid the immune response against it. In certain stages, interferons are used to cure the infection. Convalescent plasma therapy is used for patients with severe COVID-19 infection, all over the globe. A variety of antibodies fight against SARS-CoV-2 at different stages of its development and neutralize the virus.JAK inhibitors, corticosteroids, and others are used to modulate the immune response to control cytokine storms brought on by COVID-19 in its late phase. The changes in the cytokine storm and antibody reaction against SARS-CoV-2 require newly modified treatment for the patients to fight the infection. Researching about the manner of development, the immune response against the infectionandviral-mediated reactions help to find an efficient preventive and therapeutic medication.