Since age-related diseases and conditions are a growing global concern and many scientists are searching for better approaches to enhancing the work performance of the aging population, it is important to find ways to prevent and treat age-related conditions, handle inadequate nourishment and increase work-related efficiency. Exploring plant-based dietary supplements and supplements with antler products, we selected two new supplements developed and manufactured by Biolit Science and Production Association (Tomsk city). For clinical trials, thirty participants (10 males and 20 females aged from 40 to 55) were divided into two groups and administered treatment with and without nutrition plans. For the assessment of the efficacy of treatment, we monitored the autonomic nervous system dynamics, hormonal changes, and immune system. The objective performance criteria included: (a) the data obtained upon the comprehensive assessment of the autonomic nervous system, mental and emotional states; (b) the neuroendocrine system functioning; (c) the levels of cytokines as they are useful biomarkers of inflammation; and (d) bone metabolism. The subjective performance criteria included monitoring participants’ general well-being and the nature of their complaints.