Regional Left Ventricular Function Analysis By 128-Row Multi-Detector Computed ‎Tomography in Patients with Coronary Artery Disease

Hanan A. Bahaaeldin , Ibrahim A. Libda , Ahmed A. El Sammak , Ekhlas M. Hussien , Farida ‎M. El Fawal

Abstract

Purpose: The aim of this study was to estimate the role of multidetector computed tomography (MDCT) in the evaluation of LV regional wall ‎motion abnormalities (RWMA) in subjects complaining of coronary artery heart disease (CAD) and to compare MDCT data with two dimension ‎standard echocardiography (2DSE) as the standard reference.‎ Patients and Methods: Sixty subjects with supposed coronary artery heart disease were submitted to retrospective gating contrast-enhanced ‎MDCT. 10 phases of the cardiac cycle were performed to detect end-systolic and end-diastolic phases at LV short-axis view. LV Regional wall ‎motion was assessed qualitatively (visually in cine-mode) and quantitatively (measuring the percentage of systolic wall thickening on static ‎end-diastolic and end-systolic images) on cardiac short-axis view and long-axis views using a 17-segment model. 2DSE was performed within ‎two weeks before MDCT.‎ Results: Good segmental agreement was found between echocardiography and MDCT (k=0.7; p < 0.001), MDCT detected 720 (98.7%) of 729 ‎segments that showed normal motility, 172 (74.7%) of 230 segments showed hypokinesia and 49 (80.3%) of 61 segments showed akinesia or ‎dyskinesia. Regarding the diagnostic performance, the sensitivity, specificity, and accuracy of MDCT reached 80.4%, 97.4%, and 93.5%, ‎respectively, assuming 2DSE as the gold standard.‎ Conclusion: Evaluation of regional left ventricular function by using MDCT is a precise method, with good agreement with 2D ECG‎‎‎‎.