Dental prosthetics are used to replace and deal with major intraoral problems especially in the posterior regions of the oral cavity. Although, advanced prosthetic materials with better polishing features show clinical satisfactory results however oral health-related issues remain controversial. However, many studies were done and provided successful osseointegration supporting the survival of implants data and also mentioned rare complications that developed during the process. This review aims to outline and analyze potential effects on the quality of life and oral health-related issues in patients with dental prostheses. A systematic review based on the electronic search database PubMed and Springer where the data was collected to identify only English published articles, observational clinical trials, and current literature reviews that were relevant to this subject was introduced in this review. Within the limited findings of this review many retrospective studies concluded that fixed dental prosthesis is clinically acceptable to maintain a normal patient profile, comfort, function, speech, health, and esthetics.