A lot of experiments have been carried out in Saudi Arabia concerning the misuse of antibiotics and buying them without being prescribed by a doctor. However, despite all these studies, a few or none of them have appraised the parental awareness, practices and attitude toward the use of antibiotics in the treatment of URTIs in their children. As such, the objective of this experiment was to document and analyze the parental levels of knowledge, attitudes, and practices (KAP) regarding the use for upper respiratory tract infections in children. This is a cross-sectional study that was conducted across 8 cities: Riyadh, Jeddah, Taif, Makkah, Dammam, Al Ahsa, Albaha and Asir Saudi Arabia from 01/09/2019 to 26/09/2019, according to which a total of 714 parents took part in the study. Convenience sampling was the method that was used to select the participants of the experiment. The findings of the current research were found to be the same as those of the studies that were conducted before in Palestine. The researcher found out that the parents in Saudi Arabia lack adequate knowledge regarding the use of antibiotics in the treatment of URTIs and this led to their wrong practices and attitudes toward the same. Despite all these, the study established a relationship of trust between the subjects and the doctors, meaning that there is a trust in the information and recommendations that the doctors give them concerning the medications.