Abdullah Mohammed Alghamdi , Assem Mohammed Alghamdi , Saif Awadh B Alsemairi , Abdulaziz Abdullah Alangari , Mahmoud Abdullah Alabbad , Ebaa Ali Alebrahim , Rawan Ahmad Albluwi , Abdulrahman Ibrahim Almaymn , Abdulrhman Mahbob Alawfi , Hayder Saleh Alkhanjaf

Abstract

Sepsis-associated acute kidney injury (S-AKI) is a common condition found in critically ill patients that raises morbidity as well as mortality risk. Clinical and fundamental science data suggests that S-AKI is different from AKI without sepsis since it is characterized by a variety of discrete pathophysiological processes, a distinct timing profile regarding the onset or the duration, and different short- and long-term results. Physicians must have a thorough grasp of S-AKI to establish adequate diagnosis and treatment methods. To review the published literature and provide adequate coverage of S-AKI, diagnosis, and management. For articles’ selection, the PubMed search engine was used, and the following keywords were used in mesh ((“Sepsis-associated acute kidney injury"[Mesh]) AND (“diagnosis”[Mesh]) OR (“management"[Mesh])). AKI’s early detection in the presence of sepsis is critical for providing the best care and preventing additional kidney damage. Detecting AKI in the context of infection is very important since it might indicate sepsis in a patient. Injury or stress indicators combined with functional assessments may give more information than each one alone. After many types of research including large numbers of patients and randomized controlled trials (RCTs) of particular treatments, early diagnosis, fast fluid resuscitation, and early antibiotic administration remain the only interventions that improve sepsis outcomes. Fluid resuscitation alone is insufficient to provide appropriate renal perfusion pressure, thus, patients with sepsis frequently require vasopressor assistance.