Yuliya Mukhametova , Boisjon Tokhiriyon , Valeriy Poznyakovsky , Ekaterina Pastushkova , Abduvali Toshev

Abstract

As populations in many countries around the world age, the global supplement industry has been thriving for over a decade. The Russian supplements market has also experienced significant growth, with more consumers acknowledging the lack of essential nutrients in their diets. To meet the increasing demand and capture the opportunity, Russian producers of supplements seek natural bioactive compounds with proven health benefits and enhanced effectiveness. Therefore, Russian supplement manufacturers developed supplements with natural polyprenols from the needles of Siberian conifer trees. Polyprenols possess anti-inflammatory and hepatoprotective functions. Polyprenols participate in the processes of regeneration of damaged liver cell membranes, provide glycosylation reactions in the dolichol phosphate cycle during the synthesis of glycoproteins; control their biosynthesis, maintain the immune status of the cell, transport of immunoglobulins, regulate the reduction of cholesterol levels by activating the transport of dolichol from the endoplasmic reticulum to lysosomes; improve the energy metabolism of the cell, participate in oxidative phosphorylation and activation of mitochondrial function.The present study assesses existing supplements aimed at reducing cholesterol and the market potential for supplements with polyphenols.