Farag Altalbawy , Mohammed Alfadi

Abstract

The chemistry of α-(arylhydrazono)-β-ketoaldehydes has recently received considerable attention and they are frequently employed as synthons in organic synthesis and their structural features are part of biologically active compounds. Thus, the present studies research describe the novel series synthesis of 3,3'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis(2-arylhydrazono-3-oxo-propanal) 3a-i via coupling reactions of sodium 3,3'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis(3-oxoprop-1-en-1-olate) (2) with arenediazonium chloride. Condensation of the compounds 3a-i with hydrazine hydrate afforded a new series of the bis(arylazo)-terpyrazole derivatives 5a-i as the end compounds. The newly prepared structures compounds were characterized as established on their spectroscopic spectra and rudimentary evauation. In addition, the spectral electronic absorption of compounds 5 was measured in various buffer solutions. The acidity constants pK's were calculated for the prepared series and their correlations versus Hammet substituent constants were investigated. The outcomes demonstraed that the title compound 5 exist in the bis-hydrazo form 5A. Producst 5a-i were screened in vitro for antibacterial and antitumor activity toward the HepG2 cell line.