The experiment was conducted to determine differential responses of four quinoa genotypes irrigated with water at different salinity levels (800, 4000, and 8000 ppm) during the growing season (2019). The effect of the three salinity levels on quinoa growth was investigated depend on some characters including plant height, chlorophyll content, days of flowering, the weight of grains/plant, and the weight of 1000 seeds of four tested genotypes (Chenopodium quinoa Willd). According to salinity resistance indices, the Chipaya variety was the most tolerant to salinity stress while the Ollague variety was the most sensitive. The results stated that all characters were affected, especially under high salinity level conditions. In general, the most of tested traits displayed recorded obvious variations between the four genotypes and salinity levels on quinoa plants. The correlation and tolerance indices analysis of data has been calculated based on yield grain and its components. The results confirm that the tested varieties can be divided into three groups according to their performance under environmental stress compared to normal conditions.