Drug Release of Bacterial Cellulose as Antibacterial Nano Wound Dressing
Abstract
Bacterial cellulose (BC) is a natural polymer that can be utilized for many applications. Because of its renewable nature, good biocompatibility and excellent physical features of bacterial cellulose, it can be utilized in pharmaceutical, biomedical fields, and nanotechnology applications. In this study, we prepared antibiotic bacterial cellulose loaded with tetracycline hydrochloride and gentamicin, and its drug release, as well as antibacterial activity, were evaluated separately. The structure and morphology of the loaded bacterial cellulose were determined by scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR). AATCC100 test was used for antibacterial properties against Escherichia coli and Staphylococcus aureus. Ultraviolet spectrophotometry device was used to detect absorption and release process of mentioned antibacterial cellulose. By these unique specifications of bacterial cellulose layer loaded with tetracycline hydrochloride and gentamicin, we found that they may successfully serve as a wound dressing and other medical biomaterials.
