Effect of Ethanol from Extract of Tapak Liman Leaves (Elephantopus scaber Linn.) on Hematopoiesis of Anemia Mice

Yufri Aldi , Dwisari Dillasamola , Nabila Rifa


Background and Objective: Tapak Liman leaves have been long used traditionally for anemia. The dried powder form of Elephantropus scaber was extracted to produce ethanol. This study aimed to prove the hematopoietic effect of tapak liman leaf. Materials and Methods: The study was conducted for 28 days. The samples consisted of one non-anemic group and four anemic groups induced by 130 mg/kgBW chloramphenicol given every day for 14 days. In the last day, group 2, 3 and 4 were given the extract of tapak liman leaves for 10, 30 and 100 mg/kgBW; respectively. Group 5 (as a positive control) was given physiological NaCl 0.9%. The testing doses were given once a day for 14 days, and the effects were observed on day 1st , 14th, 21st, and 28th. Results: The parameters used in this study were erythrocyte, hemoglobin, reticulocyte and hematocrit counts in white mice that were analyzed by two-way ANOVA showing a significant value of (p<0.05). Conclusions: The extract of tapak liman leaves could increase hematopoietic activities; hence, it could be used as an alternative therapy for anemia.