Evaluation of Haematological Alterations in Intraperitoneal and Oral Rotenone Induced Parkinson’s Disease Wistar Rat

Suchitra Kavuri , Senthilkumar Sivanesan


In the present work, we examined intraperitoneal (3 and 6 mg/kg body weight [bw]; Rot-3-ip and Rot-6-ip, respectively) and oral (50 and 100 mg/kg bw; Rot-50-po and Rot-100-po, respectively) rotenone induced PD modeled Wistar rats to evaluate changes in various haematological parameters. While Rot-3-ip for 21 days and Rot-50-po for 28 days caused major Parkinson’s disease (PD)-related alterations, Lewy bodies were only detected in Rot-3-ip rats. The Rot-6-ip and Rot-100-po treatments caused lethal toxicity. The ip and po rotenone doses significantly (p < 0.05) and dose dependently altered several haematological variables (haemoglobin [Hb], red blood cells [RBCs], white blood cells [WBCs] and packed cell volume [PCV]).