Preventive and Curative Effects of Metformin, Nigella sativa, Punica granatum and Zingiber officinale on Male Reproductive Dysfunction in Diabetic Rats


Diabetes mellitus is a metabolic disorder, that affects almost all the cells of the body. Well documented complications of DM include, neuropathy, nephropathy, microangiopathy, and retinopathy. The negative impact of the disorder is also found in other cells, including male reproductive system. In this study, fifty adult Wistar albino male rats were used. The rats were divided into 10 groups, each group comprised of 5 rats. Diabetes was induced by intraperitoneal injection of STZ, effects of DM were observed on the sperm producing cells then preventive as well as curative effects of Metformin, Punica granatum, Nigella sativa and Zingiber officinale were observed. It was found that all the substances prevent as well as repair/cure the damage caused by DM to the seminiferous tubules and other structures. The results of this study show that Metformin though prevented and caused repair to the damaged cells as well, but was not as effective as Punica granatum, Nigella sativa and Zingiber officinale.