Taurine as a Drug for Protection of Liver and Kidney against Toxicity of Dinitrotoluene on Male Rats (Applicable Study)

Abstract

Technical grade dinitrotoluene (tg-DNT) [CH3C6H3 (NO2)2] nitroaromatic agents which are manufactured in the industries and applied in both commercial and military in all over the world and Egypt. DNT causes malfunctions in kidneys, heart, liver, testes and mammary glands in animals and human beings, which may be considered as carcinogenic in experimental animals and human. Moreover, taurine, a free β-amino acid with remarkable antioxidant activity, has important beneficial effects on the human body; hepatoprotection, nephroprotection, cardiovascular protection, hypoglycemic impact and hypolipidemicaction. Currently, taurine level in the serum is used as early marker of breast, endometrial and colon cancers. The current research was aimed to explore the potential impacts of the antioxidant properties of taurine as a protecting material on tg-DNT induced toxicity in the liver and kidney in male rats. 100 apparently healthy male rats in 4 groups were included; the first is Frank control group, mouth feeding via gavage with distilled water; the other groups were administered as following, taurine alone, tg-DNT alone (toxic group), taurine + tg-DNT (protective group) in the second, third and fourth groups, respectively. In these groups, blood biochemistry and taurine concentrations in serum were measured for all animals. Furthermore, histopathological examination studies for liver and kidney were done for all groups. The results showed that, the protective group has marked improvement in most biochemical parameters than the toxic group. Histological studies revealed a significant marked disturbance in the histopathological architectures of the kidney and liver in all toxic rats. However, marked improvements in histological architectures were observed in protective group. The results support the ameliorative effect of taurine as a protective agent against tg-DNT toxicity in experimental rats.