Written by Amelanh Sica Diakité
Published On Issue 4 Vol 13, 2024
A two-step synthesis method, initially using a microwave reactor for the preparation of reaction intermediates, allowed us to synthesize eleven 6-aryl-2,4-diamino-1,3,5-triazines 5a-k. The intermediates were biguanide derivatives 3 a-f which were synthesized under microwave irradiation for 10 min at 130°C . The 2,4-diamino-1,3,5-triazine derivatives (5a-k) were obtained with yields from 16% to 86%. The compounds synthesized were submitted to biological evaluation on twelve protein kinases, throu
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Written by Wiktoria Suchy
Published On Issue 4 Vol 13, 2024
Research conducted in recent years has significantly transformed our understanding of the role of the vascular endothelium in maintaining the overall homeostasis of the body. It has been revealed that the endothelium is responsible for synthesizing a wide range of biologically active substances that play a key role in numerous processes both in health and disease - such as hemodynamics, hemostasis, immunological responses, and regenerative processes. This extensive endocrine activity has led to
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Written by Cheickna Cissé
Published On Issue 4 Vol 13, 2024
The objective of this study was to document the plants used in traditional cough treatment for children and to conduct a phytochemical study of the two most used plants. An ethnobotanical survey was conducted among traditional sellers in the markets of Bamako. A phytochemical screening based on classic color reaction and tube precipitation methods was performed. Aluminum trichloride was used to quantify flavonoids, whereas the Folin-Ciocalteu method was utilized to quantify total polyphenols. Th
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Written by Ilie Lastovetskyi
Published On Issue 4 Vol 13, 2024
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms such as tremor and rigidity, along with non-motor symptoms like cognitive decline and depression. Current dopaminergic therapies offer symptomatic relief but fail to halt disease progression, underscoring the urgent need for novel, disease-modifying treatments. This review examines the potential of repurposed drugs from various therapeutic categories—including immunomodulatory, cardiometaboli
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