Biologically Active Complexes Based on Natural Raw Materials: Composition and Prospects for Use

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Abstract

In order to improve the absorption of biologically active chemicals and compounds with limited bioavailability, the present study examines the feasibility of mixing partly soluble arabinogalactan polysaccharides with chitosan polysaccharides. Chitosan succinate, succinic anhydrate, and arabinogalactan with covalently unbound dihydro quercitin, with weight percentages of 3.0-5.0, 2.0-4.0, 15.0-20.0, and 3.0-5.0, respectively, are all components of the physiologically active biopolymer matrix. They act as vehicles for the precise delivery of medicinal and diagnostic substances to specific cells, such as hepatocytes (parenchymal liver cells), such as enzymes, nucleic acids, vitamins, and hormones. Arabinogalactan from Siberian larch (Larix sibirica) was shown to have strong membranotropic activity in the research. Because arabinogalactan creates a binding complex with the drug being administered and engages with the cell's asialoglycoprotein receptor, it can be utilized to improve the absorption of other active components with limited bioavailability through the digestive tract. The paper also examines the effectiveness of arabinogalactan to improve the technological and functional properties of PSE-like broiler meat. The addition of arabinogalactan to sausage filling in an amount of 0.5% of the total raw materials increased the moisture-binding capacity by 5% while reducing losses during heat treatment by 6%. We can also note better peroxide and acid values during storage resulting in oxidative process inhibition and prevention of product spoilage.

The possibilities of developing a new gel complex polymer based on the polysaccharide matrix as well as its use in health-saving technologies have been considered.

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How to cite:
Vancouver
Mikhailovich PV, Tokhiriyon B, Vladimirovna PO, Vladislavovna UY, Grigorevna CN. Biologically Active Complexes Based on Natural Raw Materials: Composition and Prospects for Use. Int J Pharm Res Allied Sci. 2023;12(3):88-93. https://doi.org/10.51847/zgAyWaTFRK
APA
Mikhailovich, P. V., Tokhiriyon, B., Vladimirovna, P. O., Vladislavovna, U. Y., & Grigorevna, C. N. (2023). Biologically Active Complexes Based on Natural Raw Materials: Composition and Prospects for Use. International Journal of Pharmaceutical Research and Allied Sciences, 12(3), 88-93. https://doi.org/10.51847/zgAyWaTFRK