Hala M. Al-Moaigel, Nadeer Z. Albaik, Hassan T.Al-shehab, Abdulrahman W. Aldossary, Saif A. Abalkhail, Abdulrahman M. Alomani

Abstract

Background: The aim of this study is to estimate the incidence and prognosis of PIGN in Eastern Province of Saudi Arabia. Materials and Methods: We retrospectively collected the data of all subjects who were diagnosed and got admitted with PIGN in King Fahd hospital, Al Khobar, Saudi Arabia, reviewed and approved by Institutional Review Board at Imam Abdulrahman Bin Faisal University. Result: Fifteen subjects were identified with PIGN during the study period (2009-2018). All subjects were Saudi. The mean age was 7.27 years and the majority were males (53.3%). Eleven subjects (73.3%) had recent history of URTI, eleven subjects (73.3%) had history of gross hematuria, nine subjects (60%) had history of eye puffiness, thirteen subjects (86.7%) had edema, and eight subjects (53.3%) had a fever at presentation. BP was elevated in eleven subjects (73.3%). All subjects (100%) had microscopic hematuria, urine protein to creatinine ratio was elevated in twelve subjects (median 13), ASO titer was elevated in five subjects (62.5%), C3 was decreased in twelve subjects (80%), serum albumin was low in 12 subjects (85.7%), and ANA, IgA and C4 were normal in all tested subjects. Renal biopsy was performed in two subjects and the results confirmed the diagnosis of PIGN. Conclusion: The incidence of PIGN in our pediatric population at King Fahd University Hospital in the period from 2009-2018 was 3 cases per 100000 which indicate that (PIGN) in pediatric age group in the Eastern Province of Saudi Arabia is as common as in the developed countries.