Written by Srinivasan Nagarajan
Published On Issue 1 Vol 13, 2024
Chronic conditions known as Inflammatory Bowel Diseases (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC), have a significant impact on the quality of life experienced by patients. Innovative research is revealing complex molecular interactions between medicinal plants and diseases, advancing plant-based therapies. Typically, the primary methods for managing the condition involve using medications and making lifestyle adjustments. However, recent research indicates that medic
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Written by G. Ramya Balaprabha
Published On Issue 1 Vol 13, 2024
The field of psychology has advanced over the years in treating psychiatric disorders such as major depressive disorder (MDD), Schizophrenia, and Alzheimer's disease (AD). Depression or clinical depression is a major mental health issue characterized by chronic sadness, hopelessness, and emptiness, which diminishes the patient's quality of life. According to WHO, an estimated 3.8% of the world's population experience depression, in which 15% of depressed patients eventually die by su
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Written by Ling Xu
Published On Issue 1 Vol 13, 2024
Gastric cancer (GC) is one of the most common malignant tumors with high incidence and mortality rates. Most patients with GC are not diagnosed until the advanced stage of cancer or during tumor screening, resulting in missing the best treatment time. This study identified key modules and hub genes associated with GC by weighted gene co-expression network analysis (WGCNA). The "limma" package in R was used to identify differentially expressed genes (DEGs) in GC samples from TCGA, and a
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Written by Ridhi Joshi
Published On Issue 1 Vol 13, 2024
The phytoconstituents of the plant are directly or indirectly linked to the medicinal and advantageous qualities of the genus and are essential to the plant's self-defense against a variety of biotic and abiotic challenges. Plant genera have been divided into subcategories depending on the presence of these compounds, such as medicinal, anti-inflammatory, anti-stomachic, anti-cancer, and anti-diarrhoeal. The Convolvulaceae family, which includes the genus Distimake formerly known as Merremia
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Written by Sukni Bui
Published On Issue 1 Vol 13, 2024
Litsea cubeba (Lours.) Pers. belongs to the family Lauraceae, which occurs mainly in the tropical and sub-tropical regions worldwide. The plant gained importance for its essential oils, sesquiterpenoids, flavonoids, lignans volatile oils, and numerous secondary metabolites. The Essential oil extracted from its bark, stem, leaves can be used commercially for the preparation of medicines, insecticides, perfumes, flavors, and colognes. The secondary metabolites extracted from L. cubeba show potenti
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Written by Felix OghenemaroEnwa
Published On Issue 1 Vol 13, 2024
This study provides an overview of the incidence of parasitic infections in individuals living in rural communities, highlighting the major parasites involved, risk factors, and potential interventions to mitigate the burden. This research work is therefore aimed at determining the incidence of parasitic infections among individuals living in rural areas. This study adopted a propulsive cross-sectional survey design to select fifty (50) individuals ranging from age twelve (12) to fifty-six (56)
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Written by Ahlam Alharthi
Published On Issue 1 Vol 13, 2024
This review provides a comprehensive overview of genetic variations influencing the effectiveness and side effects of methotrexate (MTX) treatment in rheumatoid arthritis (RA) patients. It synthesizes findings on associations between genetic polymorphisms and MTX therapy outcomes, aiming to identify potential genetic markers for enhancing treatment and personalized strategies in RA. The review highlights genetic variations associated with MTX therapy effects. Variants in genes involved in MTX tr
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Written by Vladimir Nicolaevich Domatskiy
Published On Issue 1 Vol 13, 2024
Ixodes ticks are known as carriers of pathogens of many infectious diseases with natural foci. 12 species of Ixodes ticks carrying the virus of Crimean-Congo hemorrhagic fever and lumpy skin disease (dermatitis nodulares) of cattle were found in the foothill zone of Kabardino-Balkaria. In the Republic of Dagestan, Hyalomma. p. plumbeum ticks are the carriers of pathogens of taileriosis of cattle (13.6%), and the incidence of animals is 24.4%. In the Kaluga region, infection with I. ricinus
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Written by Abigail Owusu
Published On Issue 1 Vol 13, 2024
Despite advancements in cardiac transplant therapies, rejection remains a significant issue. Lovastatin, a statin drug with promising immunomodulatory effects, has garnered attention as a potential treatment for heart transplant rejection. Studies collectively highlight lovastatin's ability to influence T-cell activation, reduce acute rejection episodes, and maintain graft function. These findings offer promising avenues for enhancing transplant success rates and patient outcomes with the us
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Written by Muhammad Hayat
Published On Issue 1 Vol 13, 2024
Due to the power and high prevalence of infection and the lack of suitable medicine for the Ebola virus, research has been conducted on the discovery and introduction of anti-Ebola drugs. The purpose of the present study was to investigate the bioinformatic inhibition of Ebola virus entry and proliferation by licensed non-viral drugs. This research is a descriptive-analytical method and to carry out this investigation, first, the chemical structure of the compounds was drawn using ChemDraw Ultra
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