Written by Srinivasan Nagarajan
Published on Issue 1 Vol 13, 2024
Chronic conditions known as Inflammatory Bowel Disease (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC), have a significant impact on the quality of life experienced by patients. Innovative research is revealing complex molecular interactions between medicinal plants and diseases, advancing plant-based therapies. Usually, taking medicine and changing one's lifestyle are the main ways to manage the illness. Recent studies, however, suggest that medicinal plants may offer
Read More
Written by G. Ramya Balaprabha
Published on Issue 1 Vol 13, 2024
The field of psychology has advanced over the years in treating psychiatric disorders such as major depressive disorder (MDD), Schizophrenia, and Alzheimer's disease (AD). Depression or clinical depression is a major mental health issue characterized by chronic sadness, hopelessness, and emptiness, which diminishes the patient's quality of life. According to WHO, an estimated 3.8% of the world's population experience depression, in which 15% of depressed patients eventually die by su
Read More
Written by Ling Xu
Published on Issue 1 Vol 13, 2024
Gastric cancer (GC) is one of the most common malignant tumors with high incidence and mortality rates. Most patients with GC are not diagnosed until the advanced stage of cancer or during tumor screening, resulting in missing the best time for treatment. This study identified key modules and hub genes associated with GC by weighted gene co-expression network analysis (WGCNA). The "limma" package in R was used to identify differentially expressed genes (DEGs) in GC samples from TCGA, and a total
Read More
Written by Ridhi Joshi
Published on Issue 1 Vol 13, 2024
The phytoconstituents of the plant are directly or indirectly linked to the medicinal and advantageous qualities of the genus and are essential to the plant's self-defense against a variety of biotic and abiotic challenges. Plant genera have been divided into subcategories depending on the presence of these compounds, such as medicinal, anti-inflammatory, anti-stomachic, anti-cancer, and anti-diarrhoeal. The Convolvulaceae family, which includes the genus Distimake formerly known as Merremia
Read More
Written by Sukni Bui
Published on Issue 1 Vol 13, 2024
Litsea cubeba (Lour.) Pers. belongs to the family Lauraceae, which occurs mainly in the tropical and sub-tropical regions worldwide. The plant gained importance for its essential oils, sesquiterpenoids, flavonoids, lignans volatile oils, and numerous secondary metabolites. The Essential oil extracted from its bark, stem, and leaves can be used commercially for the preparation of medicines, insecticides, perfumes, flavors, and colognes. The secondary metabolites extracted from L. cubeba show pote
Read More
Written by Felix OghenemaroEnwa
Published on Issue 1 Vol 13, 2024
This study provides an overview of the incidence of parasitic infections in individuals living in rural communities, highlighting the major parasites involved, risk factors, and potential interventions to mitigate the burden. This research work is therefore aimed at determining the incidence of parasitic infections among individuals living in rural areas. This study adopted a propulsive cross-sectional survey design to select 50 individuals ranging from age 12 to 56 years who met the inclusion c
Read More
Written by Ahlam Alharthi
Published on Issue 1 Vol 13, 2024
This review provides a comprehensive overview of genetic variations influencing the efficacy and side effects of methotrexate (MTX) treatment in rheumatoid arthritis (RA) patients. It synthesizes findings on the associations between genetic polymorphisms and MTX therapy outcomes, aiming to identify potential genetic markers for enhancing treatment and personalized strategies in RA. The review highlights genetic variations associated with MTX therapy effects. Gene variants involved in MTX transpo
Read More
Written by Vladimir Nicolaevich Domatskiy
Published on Issue 1 Vol 13, 2024
Ixodes ticks are known as carriers of pathogens of many infectious diseases with natural foci. The purpose of the study is to analyze the literature on the infection of Ixodes ticks with pathogens of infectious diseases with natural foci in the territory of the Russian Federation. RSCI, Cyberleninka, PubMed, WoS, and Scopus are just a few of the electronic databases that contain information on Ixodes ticks as natural foci for infectious disease pathogens. This information served as the foundatio
Read More
Written by Abigail Owusu
Published on Issue 1 Vol 13, 2024
Despite advancements in cardiac transplant therapies, rejection remains a significant issue. Lovastatin, a statin drug with promising immunomodulatory effects, has garnered attention as a potential treatment for heart transplant rejection. Studies collectively highlight the ability of lovastatin to influence T-cell activation, reduce episodes of acute rejection, and maintain graft function. These findings offer promising avenues for enhancing transplant success rates and patient outcomes with th
Read More
Written by Muhammad Hayat
Published on Issue 1 Vol 13, 2024
Due to the power and high prevalence of infection and the lack of suitable medicine for the Ebola virus, research has been conducted on the discovery and introduction of anti-Ebola drugs. The present study aimed to investigate the bioinformatic inhibition of Ebola virus entry and proliferation by licensed non-viral drugs. This study is a descriptive-analytical method and to carry out this investigation, first, the chemical structure of the compounds was drawn using ChemDraw Ultra 10.0 software,
Read More
Written by James Anderson
Published on Issue 1 Vol 13, 2024
Drug–target affinity is commonly interpreted through the geometry of a representative bound complex, yet an experimentally resolved or computationally predicted structure does not specify how frequently that conformation is occupied, how it is reached, or how alternative protein, ligand, and solvent states contribute to binding. This Perspective argues that affinity is more appropriately interpreted as an ensemble property emerging from coupled conformational populations and their redistribution
Read More
Written by Hans Müller
Published on Issue 1 Vol 13, 2024
Allosteric drugs are commonly explained with structures: a ligand occupies a distal pocket, the protein adopts a different conformation, and activity changes at a functional site. Molecular dynamics (MD) complicates this account because it can reveal state populations, transient pockets, coupled fluctuations and communication routes that are absent from endpoint structures. Yet the appearance of motion in a trajectory does not itself establish a new mechanism. This Perspective asks a narrower qu
Read More
Written by Sofía Martínez
Published on Issue 1 Vol 13, 2024
Applicability domains are intended to delimit the region in which a quantitative structure–activity relationship model has defensible predictive support. In practice, however, domain assessment is often compressed into an administrative decision: a query compound is classified as inside or outside a boundary, after which the binary label is allowed to stand in for prediction reliability. This Perspective argues that this compression obscures several analytically distinct quantities. Chemical-spa
Read More
Written by Kenji Tanaka
Published on Issue 1 Vol 13, 2024
Feature importance has become a common language for explaining quantitative structure–activity relationship and molecular machine-learning models, yet an attribution is only one kind of interpretive claim. A descriptor, atom, bond, fragment, or learned concept can receive high importance without establishing that the explanation is stable across model specifications, faithful to the model’s actual decision process, representative of global behaviour, mechanistically causal, or useful for a medic
Read More
IJPRAS
