Ixodes ticks are known as carriers of pathogens of many infectious diseases with natural foci. The purpose of the study is to analyze the literature on the infection of Ixodes ticks with pathogens of infectious diseases with natural foci in the territory of the Russian Federation. RSCI, Cyberleninka, PubMed, WoS, and Scopus are just a few of the electronic databases that contain information on Ixodes ticks as natural foci for infectious disease pathogens. This information served as the foundation for the analysis and scientific approach, which employed analytical, comparative, and systematic study techniques. 12 species of Ixodes ticks carrying the virus of Crimean-Congo hemorrhagic fever and lumpy skin disease (dermatitis nodulares) of cattle were found in the foothill zone of Kabardino-Balkaria. In the Republic of Dagestan, Hyalomma plumbeum ticks are the carriers of pathogens of taileriosis of cattle (13.6%), and the incidence of animals is 24.4%. In the Kaluga region, infection with Ixodes ricinus Borrelia reaches 16.9%, and with Dermacentor reticulatus, it is at 12.3%. In the Omsk region, mixed infection with pathogens of infectious diseases with natural foci was found in 16.5% of Ixodes ticks. In the south of Eastern Siberia, the infection rate of taiga ticks with tick-borne encephalitis virus ranged from 0.5-4.5%, and on average it was about 1.2%. Infection of taiga ticks with Borrelia ranges from 10-34%, on average reaching 19%, of which 2.5% cases are with a high degree of infection. In Khabarovsk, 18.3% of ticks were infected with Borrelia, and the tick-borne encephalitis virus was found in 2.4% of ticks. In the south of Primorsky Krai, 13.3% of Ixodes persulcatus ticks have pathogens of viral and bacterial infections. In the Republic of Sakha (Yakutia), the virulence of ticks was 5.7-9.8%. The biological type of tick development does not change the fundamental side of brucella reservation and transmission of infection to healthy animals.