Hyperlipidemia and obesity represent significant global health challenges associated with heightened risks of angina, atherosclerosis, and stroke due to elevated blood lipid levels. Exploring natural agents as potential therapeutic interventions is promising in addressing these conditions. In this study, the antihyperlipidemic and anti-obesity effects of ethanolic extract from Parmotrema tinctorum were evaluated using an olive oil-induced hyperlipidemic rat model. Rats were divided into distinct treatment groups, including simvastatin, distilled water (control), and two doses of the extract (200 mg/kg and 400 mg/kg). The experiment was conducted over 28 days. Administration of Parmotrema tinctorum extract led to significant reductions in body and liver weight gain. The serum lipid profile exhibited dose-dependent decreases in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C). Additionally, there were notable reductions in the atherogenic index and blood glucose levels. The observed effects were attributed to potential anorectic actions mediated through the central nervous system. The extract did not affect gastric emptying and demonstrated inhibition of de novo cholesterol biosynthesis. This study underscores the potential of ethanolic extract from Parmotrema tinctorum as a dual-action therapeutic agent for addressing hyperlipidemia and obesity. The findings highlight its ability to modulate lipid metabolism, suggesting implications for managing cardiovascular and metabolic disorders. Further research is needed to elucidate the underlying mechanisms of its effects and to explore its potential application in clinical settings.
IJPRAS
