Creatine is a naturally occurring compound found in muscles that play a vital role in energy metabolism. It has been shown to have beneficial effects on skeletal muscle function and exercise performance, but recent studies have explored its potential role in various fields of medicine. The study aimed to analyze the accessible literature and illustrate the current state of knowledge regarding the use of creatine in these settings, as well as make predictions for further research. The association between low creatine concentrations and poorer mental well-being has been proven in the central nervous system. After many studies and insightful conclusions about the molecular mechanisms of creatine's action in the brain and the finding that it acts as a neurotransmitter, creatine began to be successfully studied as an antidepressant - both in monotherapy and as an adjunct to treatment with SSRI drugs. Years of research have shown that creatine acts through various and not fully understood mechanisms in the course and recovery of stroke. The use of creatine as an additional therapy in stroke prevention for high-risk groups and rehabilitation of stroke patients seems possible shortly. One of the most important aspects of chronic heart failure is the metabolic dysfunction that occurs in cardiomyocytes, including the impairment of the CR/PCR/ATP shuttle. Several studies investigating the role of creatine supplementation in patients with cardiovascular diseases have presented different findings. Therefore, creatine appears as a promising substance with supportive effects in the above-mentioned conditions; however, further research is needed to confirm that the benefit outweighs the risks.
IJPRAS
