Hepatoprotective Activity of Calycopteris floribunda on Clopidogrel and Atorvastatin Induced Hepatic Damage in Rodents
Abstract
Preclinical testing hepatoprotective potential of hydroalcoholic leaf extract of Calycopteris floribunda against liver damage caused by atorvastatin and clopidogrel. Atorvastatin and clopidogrel were delivered intraperitoneally for 14 days at 80mg/kg and 20mg/kg respectively, while leaf extract was given orally for the same period at 200mg/kg and 400mg/kg. To evaluate the impact of the leaf extract on the atorvastatin and clopidogrel-induced liver damage, many biochemical markers, Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), total protein, and serum alkaline phosphatase were measured. Blood samples from mice given hydroalcoholic Calycopteris floribunda leaf extract showed a noteworthy decrease in serum indicators, suggesting that the leaf extract had an impact on the hepatocytes' ability to operate normally again. On the other hand, the mice receiving atorvastatin and clopidogrel treatment showed increased levels, which suggested serious liver injury. Silymarin (100 mg/kg) was given as a benchmark. The current investigation found that Calycopteris floribunda hydroalcoholic extract significantly protected the liver against atorvastatin and clopidogrel-induced hepatic damage.
Keywords: Calycopteris floribunda, SGOT, SGPT, TP
