Written by Venkateswara Raju Kalidindi
Published On Issue 2 Vol 13, 2024
Drug impurity profile studies have changed significantly during the past ten years, as demonstrated by pharmacopeia and regulatory standards. This review article aims to give viewers a thorough understanding of the numerous facts of impurity profiling about regulatory criteria. Comprehensive information on residual solvents, water impurities, elemental impurities, carcinogenicity, and an overview of the most critical components of genotoxic contaminants. To ensure the drug products fulfill the m
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Written by M Miskhat-Ul-Jannat
Published On Issue 2 Vol 13, 2024
The current study aimed to assess the phytochemical profile of Macaranga indica (M. indica) leaves, as well as their antioxidant, thrombolytic, and neuropharmacological activities. Methanol extract from M. indica (MEMI) Wight leaves was used to investigate these activities to validate the therapeutic profile using a well-established method. GraphPad Prism, version 9.4.1 was used to analyze the experimental results. In vitro, the antioxidant DPPH free radical scavenging assay yielded an IC50 valu
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Written by Mahendra Kumar Sahu
Published On Issue 2 Vol 13, 2024
Molecular docking serves as a crucial computational tool in the realm of drug discovery and development, aimed at understanding the interactions between small molecules and target proteins. This study delves into the objective of elucidating the evolution of molecular docking techniques, their current applications, and potential future directions. Through a comprehensive review of the literature and analysis of recent advancements, this study provides insights into the methodologies employed in
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Written by Jada Naga Lakshmi
Published On Issue 2 Vol 13, 2024
The present study aimed to test the preclinical hepatoprotective potential of hydroalcoholic leaf extract of Calycopteris floribunda (C. floribunda) against liver damage caused by atorvastatin and clopidogrel. Atorvastatin and clopidogrel were delivered intraperitoneally for 14 days at 80 mg/kg and 20 mg/kg, respectively, while leaf extract was given orally for the same period at 200 mg/kg and 400 mg/kg. To evaluate the impact of the leaf extract on the atorvastatin and clopidogrel-induced liver
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Written by Ankita Awasthi
Published On Issue 2 Vol 13, 2024
The present study investigates the in vitro anti-obesity potential of Anethum graveolens L. (Family Apiaceae) dill seed cake (DSC). DSC contained dietary fibers, proteins, lignans, and phenolic compounds. Food rich in dietary fiber is vital in lowering dyslipidemia, complications of metabolic disorders, and obesity. DSC was obtained after oil extraction of the dill seed. Physicochemical characterization and lignan profiling were performed by HPLC. An in vitro study assessed the degree of hydroly
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Written by Ranjithkumar Murugesan
Published On Issue 2 Vol 13, 2024
An ethnobotanical study was carried out among Mannan, Urali, and Paliyan communities at Kozhimala and Chakkupallom villages of Idukki dist, Kerela. Information on one hundred plants used by them as a source of medicine for various ailments was collected through a questionnaire. Totally 68 plant species were collected from the Mannan community, 16 from the Urali, and another 16 from the Paliyan community. The plant parts used as sources of medicine by targeted tribes were, leaves (52%), followed
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Written by Vincent Taah
Published On Issue 2 Vol 13, 2024
This study investigates the effectiveness and healthcare perceptions of Tamsulosin, an off-label medication for kidney stone management. Despite the documented benefits, the quest for alternative treatments like Tamsulosin persists, driven by its advantages and patient satisfaction levels. This research includes a literature review and a survey of pharmacy students’ opinions on Tamsulosin, aiming to bridge the knowledge gap. This study, which involved 38 first-year professional pharmacy students
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Written by Peter K. Uduagbamen
Published On Issue 2 Vol 13, 2024
Antiplatelet therapy used in preventing cardiovascular events in chronic kidney disease may be associated with higher risks of bleeding, low efficacy from fewer occlusive atherosclerotic disease), attenuation of the inflammatory process, and changes in the haemogram. We prospectively determined the kidney function, the haemogram, and the lipid profile of participants with and without antiplatelet therapy. The population with a mean age of 69.21 ± 11.73 years, had more women (65.88%) (P = 0.001).
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Written by Tadikonda Rama Rao
Published On Issue 2 Vol 13, 2024
Three primary phenotypes in psychiatry have been the focus of pharmacogenetic studies: the development of side effects related to psychotropic drug treatment, the clinical effectiveness of antipsychotic drugs, and the efficacy of antidepressant medications. The present study aimed to provide a comprehensive review of pharmacogenomics and precision medicine in psychiatry. Pharmacokinetic or pharmacodynamic effects are the two categories into which pharmacogenetic studies of antidepressants can be
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Written by Sara Green
Published On Issue 2 Vol 13, 2024
Personalized medicine refers to a set of diagnostic, treatment, and prevention activities and approaches based on which patients are classified according to their personal characteristics and medical procedures are performed for them. The purpose of this article is to investigate the importance of personalized medicine, the factors that cause people to differ in their response to treatment, the methods and techniques used to achieve the goals of personalized medicine, and finally to use this met
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