Written by Venkateswara Raju Kalidindi
Published on Issue 2 Vol 13, 2024
Drug impurity profile studies have changed significantly during the past ten years, as demonstrated by pharmacopeia and regulatory standards. This review article aims to give viewers a thorough understanding of the numerous facts of impurity profiling about regulatory criteria. Comprehensive information on residual solvents, water impurities, elemental impurities, carcinogenicity, and an overview of the most critical components of genotoxic contaminants. To ensure the drug products fulfill the m
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Written by M Miskhat-Ul-Jannat
Published on Issue 2 Vol 13, 2024
The current study aimed to assess the phytochemical profile of Macaranga indica (M. indica) leaves, as well as their antioxidant, thrombolytic, and neuropharmacological activities. Methanol extract from M. indica (MEMI) Wight leaves was used to investigate these activities to validate the therapeutic profile using a well-established method. GraphPad Prism, version 9.4.1 was used to analyze the experimental results. In vitro, the antioxidant DPPH free radical scavenging assay yielded an IC50 valu
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Written by Mahendra Kumar Sahu
Published on Issue 2 Vol 13, 2024
Molecular docking serves as a crucial computational tool in the realm of drug discovery and development, aimed at understanding the interactions between small molecules and target proteins. This study delves into the objective of elucidating the evolution of molecular docking techniques, their current applications, and potential future directions. Through a comprehensive review of the literature and analysis of recent advancements, this study provides insights into the methodologies employed in
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Written by Jada Naga Lakshmi
Published on Issue 2 Vol 13, 2024
The present study aimed to test the preclinical hepatoprotective potential of hydroalcoholic leaf extract of Calycopteris floribunda (C. floribunda) against liver damage caused by atorvastatin and clopidogrel. Atorvastatin and clopidogrel were delivered intraperitoneally for 14 days at 80 mg/kg and 20 mg/kg, respectively, while leaf extract was given orally for the same period at 200 mg/kg and 400 mg/kg. To evaluate the impact of the leaf extract on the atorvastatin and clopidogrel-induced liver
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Written by Ankita Awasthi
Published on Issue 2 Vol 13, 2024
The present study investigates the in vitro anti-obesity potential of Anethum graveolens L. (Family Apiaceae) dill seed cake (DSC). DSC contained dietary fibers, proteins, lignans, and phenolic compounds. Food rich in dietary fiber is vital in lowering dyslipidemia, complications of metabolic disorders, and obesity. DSC was obtained after oil extraction of the dill seed. Physicochemical characterization and lignan profiling were performed by HPLC. An in vitro study assessed the degree of hydroly
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Written by Ranjithkumar Murugesan
Published on Issue 2 Vol 13, 2024
An ethnobotanical study was carried out among Mannan, Urali, and Paliyan communities at Kozhimala and Chakkupallom villages of Idukki dist, Kerela. Information on one hundred plants used by them as a source of medicine for various ailments was collected through a questionnaire. Totally 68 plant species were collected from the Mannan community, 16 from the Urali, and another 16 from the Paliyan community. The plant parts used as sources of medicine by targeted tribes were, leaves (52%), followed
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Written by Vincent Taah
Published on Issue 2 Vol 13, 2024
This study investigates the effectiveness and healthcare perceptions of Tamsulosin, an off-label medication for kidney stone management. Despite the documented benefits, the quest for alternative treatments like Tamsulosin persists, driven by its advantages and patient satisfaction levels. This research includes a literature review and a survey of pharmacy students’ opinions on Tamsulosin, aiming to bridge the knowledge gap. This study, which involved 38 first-year professional pharmacy students
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Written by Peter K. Uduagbamen
Published on Issue 2 Vol 13, 2024
Antiplatelet therapy used in preventing cardiovascular events in chronic kidney disease may be associated with higher risks of bleeding, low efficacy from fewer occlusive atherosclerotic disease), attenuation of the inflammatory process, and changes in the haemogram. We prospectively determined the kidney function, the haemogram, and the lipid profile of participants with and without antiplatelet therapy. The population with a mean age of 69.21 ± 11.73 years, had more women (65.88%) (P = 0.001).
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Written by Tadikonda Rama Rao
Published on Issue 2 Vol 13, 2024
Three primary phenotypes in psychiatry have been the focus of pharmacogenetic studies: the development of side effects related to psychotropic drug treatment, the clinical effectiveness of antipsychotic drugs, and the efficacy of antidepressant medications. The present study aimed to provide a comprehensive review of pharmacogenomics and precision medicine in psychiatry. Pharmacokinetic or pharmacodynamic effects are the two categories into which pharmacogenetic studies of antidepressants can be
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Written by João Silva
Published on Issue 2 Vol 13, 2024
Ligand–receptor affinity is often treated as the defining variable of active nanocarrier targeting, yet affinity can operate only after a carrier remains systemically available, reaches an accessible vascular segment, crosses or engages the endothelial barrier, traverses tissue, retains a biologically exposed ligand, and encounters a sufficiently available receptor. This Perspective argues that these preceding events should be treated as conditional access gates rather than background pharmacoki
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Written by Emma Wilson
Published on Issue 2 Vol 13, 2024
Active targeting is commonly designed as though the molecular identity presented by a nanomedicine at administration remains the identity that governs subsequent biological recognition. Protein-corona formation challenges that assumption. Adsorption, exchange, conformational rearrangement, compartment-specific replacement, and intracellular remodeling can alter both access to engineered ligands and exposure of newly acquired protein motifs. The resulting carrier may therefore retain, attenuate,
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Written by Mark Anderson
Published on Issue 2 Vol 13, 2024
Supersaturating formulations are commonly judged by how high and how long dissolved drug concentrations remain above equilibrium solubility. That description is incomplete because the pharmaceutical value of supersaturation depends on competing rates: generation of the supersaturated state, redistribution into drug-rich or precipitated phases, and removal of molecularly available drug by absorption. Evidence from amorphous solid dispersions, cocrystals, lipid-based systems, biorelevant transfer
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Written by Sara Al-Fahd
Published on Issue 2 Vol 13, 2024
Amorphous solid dispersions (ASDs) are commonly developed to increase the apparent solubility and dissolution of poorly water-soluble drugs, yet formulation success cannot be defined by amorphization or physical stability alone. Polymer selection, drug loading, molecular interactions, moisture exposure, hydrated-state phase behavior, precipitation, downstream dosage-form composition, and absorptive flux can alter stability and performance in different directions. This systematic review examines
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