Written by Deep Kwatra
Published on Issue 3 Vol 13, 2024
One of the methods of cancer treatment is radiotherapy. Although radiation resistance and toxicity in normal cells limit the use of radiotherapy in some specific anatomical situations, the use of substances that increase the radiation sensitivity of cancer cells while minimizing toxicity to normal cells can be beneficial. The present study aimed to investigate the radio-sensitizing effect of tolmetin in radiotherapy treatment on human colon cancer cells. In this study, human clone HT-29 cancer c
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Written by Ranjithkumar Murugesan
Published on Issue 3 Vol 13, 2024
The present study focused on lab-scale biotreatment of chromium electroplating effluent using mixed bacterial strains. The electroplating effluent-contaminated soil sample was collected and sixteen bacterial colonies were isolated and identified through morphological and biochemical characteristics. All sixteen bacterial isolates were screened for metal tolerance using a nutrient agar medium incorporated with chromium metal ions. Of the sixteen bacterial isolates, only four bacterial strains wer
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Written by Aanchal Kumari
Published on Issue 3 Vol 13, 2024
The use of muscle-enhancing steroids, particularly anabolic-androgenic steroids (AAS), has sparked widespread concern about their effects on cardiovascular health, notably their link to heart attacks. This study provides a comprehensive assessment of the link between muscle-enhancing drugs and heart attacks. It investigates the physiological pathways by which steroids might contribute to a variety of cardiovascular issues such as hypertension (high blood pressure), dyslipidemia (abnormal cholest
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Written by Ramdas Bhat
Published on Issue 3 Vol 13, 2024
Hyperlipidemia and obesity represent significant global health challenges associated with heightened risks of angina, atherosclerosis, and stroke due to elevated blood lipid levels. Exploring natural agents as potential therapeutic interventions is promising in addressing these conditions. In this study, the antihyperlipidemic and anti-obesity effects of ethanolic extract from Parmotrema tinctorum (P. tinctorum) were evaluated using an olive oil-induced hyperlipidemic rat model. Rats were divide
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Written by Bwalya A. Witika
Published on Issue 3 Vol 13, 2024
The treatment of infectious and autoimmune diseases has experienced many changes in the past few years. Currently, cancer treatment is usually based on pathological and clinical methods. The most common cancer treatment is limited to chemotherapy, radiation therapy, and surgery, however, the treatment is still not optimal. Common problems in some diseases treatment, especially cancer, include non-specific and systematic distribution of medicinal agents, insufficient drug concentration at the ope
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Written by Maksym Sikora
Published on Issue 3 Vol 13, 2024
Creatine is a naturally occurring compound found in muscles that play a vital role in energy metabolism. It has been shown to have beneficial effects on skeletal muscle function and exercise performance, but recent studies have explored its potential role in various fields of medicine. The study aimed to analyze the accessible literature and illustrate the current state of knowledge regarding the use of creatine in these settings, as well as make predictions for further research. The association
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Written by Youssef Hariri
Published on Issue 3 Vol 13, 2024
Pharmacogenomic evidence is often summarized by asking whether a gene–drug pair is actionable. That formulation is useful for cataloguing knowledge but too coarse for many prescribing decisions. The same gene can support different recommendations across drugs, a pharmacokinetic association can remain clinically nonactionable, a genotype-predicted phenotype can be altered by assay limitations or phenoconversion, and the value of genetic information can change according to whether the immediate ta
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Written by David Osei
Published on Issue 3 Vol 13, 2024
Pharmacogenomic implementation has largely been built around recurrent alleles whose population frequencies, functional effects, and clinical consequences are sufficiently characterized to support reproducible genotype-to-phenotype translation. Rare functional variants expose the limits of this architecture. Their clinical interpretation is difficult not simply because they are uncommon, but because variant detection, molecular function, pharmacological consequence, phenotype assignment, and pre
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Written by Kristian Eriksen
Published on Issue 3 Vol 13, 2024
Biosimilarity is commonly described as a totality-of-evidence judgment, but that phrase can obscure a central inferential problem: structural, functional, pharmacokinetic, pharmacodynamic, immunogenicity, and clinical evidence do not interrogate the same uncertainty with equal sensitivity. This Current Opinion argues that biosimilarity is better understood as structured reconciliation across evidence classes. Analytical characterization interrogates product attributes directly; functional assays
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Written by Mikko Lahtinen
Published on Issue 3 Vol 13, 2024
Immunogenicity assessment in biosimilar development spans analytically distinct questions. Molecular or product differences may create theoretical immunogenicity concerns, anti-drug antibody assays detect immune responses under method-dependent conditions, and only a subset of detected responses has demonstrable pharmacokinetic, pharmacodynamic, efficacy, or safety consequences. Treating these observations as interchangeable can exaggerate the significance of analytical differences or antibody p
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