Alzheimer's disease is a chronic progressive polypathogenic neurodegenerative disease in which the combination of various mechanisms and risk factors and the appearance of amyloid plaques and neurofibrillary tangles cause anatomic, cellular and molecular changes, leading to a disorder of cortical functions, memory deficits, behavioral and functional disorders and total disintegration of intellectual and psychic activities.The up-to-date necessity of application of new effective drugs has bee
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Homeostatic model of assessment (HOMA) is a statistical method for assessing pancreatic β – cell function (HOMA - β) and insulin resistance (HOMA – IR). Both are calculated using fasting plasma glucose (FPG) and insulin but with different formulae. A modified form of HOMA is emerging using Connective Peptide (C - Peptide) concentration, but studies based on this have been very limited. More than 500 research papers have been published about the use of HOMA to assess Diabete
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Biopolymer nanoparticles are molecules of interest in the direction of generation of new pre-diagnostic and treatment strategies with improved efficacy and specificity. Several methods have been developed to produce biopolymer nanoparticles. These biopolymer nanoparticles had distinct properties such as size and charge according to the production method affecting their targeting and drug encapsulation abilities. The present review highlighted the progress in the development of theronostic nanopa
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The potential application of Truffle (Terfeziaceae) and Desert Date tree (Balanites aegyptiaca) for modulating the diabetes mellitus related symptoms has gained much interest. However, less firm evidence has come from data to increase the understanding of the mechanism by which Truffle and Balanites protect pancreatic β-cells. The present study aimed to evaluate the effect of methanolic extract of Truffle and Balanites aegyptiaca on the fasting blood glucose (FBG) level; the changes in panc
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Objective: To investigate RANKL and OPG serum concentrations and the RANKL/OPG ratio in patients diagnosed with chronic periodontitis and attending dental school clinics in Makkah, Saudi Arabia. Methods : Patients seeking dental treatment at the Faculty of Dentistry Clinic, Umm Al Qura University were divided into periodontitis and control groups based on their clinical findings. Periodontitis was diagnosed in patients with a PD >4mm or CAL >3mm at more than 30% of the examined sites
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This research was carried out in the College of Medicine at the University of Taif, Kingdom of Saudi Arabia. It included a random sample of medical students in 4th, 5th and 6th years (males and females). Data were collected using a semi-structured, self-administered questionnaire, including comprehensive, anonymous demographic and socioeconomic data, lifestyle factors, health related quality of life using the WHOQOL-BREF questionnaire, other health-related data, social support, as assessed using
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Lake Manzala Engineered Wetland project (LMEWP) is a constructed wetland that has been designed for treating drainage water coming from Bahr El-Baqar drain. In this study, the concentration of heavy metals (Cu, Zn and Pb) in water, sediment and different organs of Phragmitesaustralis collected from LMEWP seasonally. The aim of this study was to determine the dynamics of distribution of metals in different parts of phragmitesaustralis, and to determined the bioaccumulation factor (BCF) in differe
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Background : CKD is prevalent in most parts of the world. CKD can be prevented and controlled by controlling its underline causes. Therefore, the objective of the present study was to assess the knowledge and perception toward CKD prevention and control in Saudi Arabia. Methodology: This was a prospective descriptive study which included 783 apparently healthy Saudi volunteers, their ages ranged from 20 to 65 years with the mean age of 37 years. A purposeful questionnaire was designed and
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The present study was planned to investigate the protective impact of curcumin on hepatotoxicity of paracetamol in male albino rats. Thirty-five male albino rats were allocated into seven equal groups, each of five rats, 1st group was kept as control, 2nd group orally administered tween 80 (0.5 ml/200 g b. wt) for 15 days, 3rd group received silymarin (200 mg/kg b. wt) orally for 15 days, 4th group received curcumin (200 mg/kg b. wt) orally for 15 days, 5th group orally administered paracetamol
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Background: Cardiovascular Diseases (CVD) are considered an overwhelming health burden in Saudi Arabia, greatly aggravated with the increasing rates of Diabetes Mellitus (DM) and obesity. Osteoprotegerin (OPG) is one of the tumor necrosis factor receptors, commonly associated with coronary heart diseases. This study examines the possible correlation among OPG with both DM and CVD. Methods: The study was conducted in Jeddah, Saudi Arabia and included 201 subjects. They were divided into four matc
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Technical grade dinitrotoluene (tg-DNT) [CH3C6H3 (NO2)2] nitroaromatic agents which are manufactured in the industries and applied in both commercial and military in all over the world and Egypt. DNT causes malfunctions in kidneys, heart, liver, testes and mammary glands in animals and human beings, which may be considered as carcinogenic in experimental animals and human. Moreover, taurine, a free β-amino acid with remarkable antioxidant activity, has important beneficial effects on the hu
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The prescription composition and the technology of a new type of specialized product - biologically active additive BAA have been scientifically grounded. The pharmacological properties and functional orientation of the active principles of the formulation components of the dietary supplements were studied, which made it possible to determine the quantitative and qualitative composition of the formulation which has a synergistic effect on metabolic processes in the presence of deforming osteoart
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It has been well reported that fatigue is an important factor which hinders performance. The resultant effect of it is loss of co-ordination and efficiency. The main aim of this investigation was to find out the effect of fatigue on muscular co-ordination among rifle shooters. Ten rifle shooters aged between 22-28 years were selected as subjects. The index of muscular co-ordination was tested with three series. A steadiness tester was used with the diameters of 0.5, 0.31, 0.25, 0.18, 0.15, 0.12,
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Aim: To evaluate the internal adaptation of some dental adhesive restorative material (Nano-composite resin /Biodentine, Nanocomposite resin / Nano- resin-modified glass ionomer and Nano-composite resin) to the primary dentinal surface using micro-computed tomography (Micro-CT) Materials and methods: Forty-five extracted primary molars, due to caries or orthodontic reasons, were collected provided that it has an intact buccal/ lingual surface(s) and one half to two-thirds of root length. The sel
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High fat diet induces excessive body fat storing by increasing mass of adipose tissue which leads to lipid profile abnormalities. Artichoke is a plant that traditionally used for treatment of various diseases. This research aimed to study the role of supplementing low or high doses of water extract of artichoke leaves in rats fed HFD. In this regard, four rat groups were established as follows: control group, high fat diet group, Low dose artichoke+ HFD group (600 mg /kg b.w/day) after three wee
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Aim: This study was designed to evaluate the therapeutic potential of adipose tissue-derived mesenchymal stem cells (AT-MSCs) compared to bone marrow-derived mesenchymal stem cells (BM-MSCs) on the regeneration of surgically created cleft alveolus in dogs. Methods: Split mouth experimental study was performed on twelve healthy mongrel dogs. The dogs were divided into two groups (A and B): Ingroup A, the surgically created alveolus was transplanted with AT-MSCs, scaffold and growth factors at the
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This cross-sectional research was carried out in the College of Medicine at the University of Taif, Kingdom of Saudi Arabia. It included a random sample of medical students in 4th, 5th and 6th years (males and females). Data were collected using a semi-structured, self-administered questionnaire, including comprehensive, anonymous demographic and socioeconomic data, lifestyle factors, health related quality of life, social support, student’s academic motivation, the past year grade point a
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Increased body weight affects the whole body including the immune response, and leads to a state of non-specific inflammation, which leads to increased incidence of inflammatory diseases. The aim of this study was to determine the relationship between adiposity and the hematological profile, and serum concentrations of glucose, C-reactive protein (CRP), some pro-inflammatory [leptin, resistin, interlukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α)] and anti-inflammatory (adiponectin)
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Colon cancer ranks as one of the most incidental and death malignancies worldwide representing 9% of all new cancer cases worldwide and affecting more than 1 million people every year. Colon cancer is the best-understood tumor from a genetic perspective. In Saudi Arabia, CRC is the second most prevalent kind of cancer, which has been ranked as the first among men (10.6%) and the third among women (8.9%). In 2004, the World Health Organization (WHO) reported a mortality rate of CRC in Saudi Arabi
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Damage to spinal cord and its subsequent neurological deficits have been recognized as the complications of scoliosis repair surgery. Wake up test has been a safe, simple and reliable method to recognize such complications. Dexmedetomidine and Sevoflurane were the main anaesthetics for a 14 year old girl who underwent a scoliosis repair surgery with the intra operative wake-up test and hemodynamic stability. The analgesic property of Dexmedetomidine was complemented by the continuous Fentanyl in
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New hydrogels based on (MAA) and (NVP) copolymers crosslinked with (BAA), were prepared by free radical cross-linking copolymerization, with a NVP percent molar composition of 10, 47.5 and 85. These hydrogels have been characterized by (FTIR), (SEM), (TGA /DSC) coupling. The results show four steps of degradation. The degradation rate is inversely proportional to the mole percent of NVP, and SEM shows that the hydrogels have a pore size between 7.14 to 13.33 μm .
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Background: The long-acting permanent method (LAPM) of contraception has been uncommonly by Indonesian women. However, few Indonesian women have switched their contraceptive methods into LAPMs, a cost effective method to limit the number of children with low odds of failure. The aim of this study was to explore the reasons of switching contraceptive methods into LAPMs by currently married Indonesian women aged 15-49 years old. A cross-sectional study was performed using a multistage cluster desi
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Written by Safaa Y. Qusti
Published On Issue 1 Vol 8, 2019
Inflammation may play a role in the pathogenesis of gestational diabetes mellitus (GDM) and also, it is one of the most popular pregnancy complications. The goal of the research was to study the association exists among common many forms in the stimulate area (-308G/A) of the TNF-alpha gene and increased danger for become better of GDM in Saudi pregnant women population.GDM and healthy subjects were genotyped with PCR- RFLP technique. No association was noticed among the TNF-α -308 G/A in
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Written by Alghumuy KhalafHelal Q.
Published On Issue 1 Vol 8, 2019
Background: The increased recognition of patients' rights has been related to using fitness care offerings. Professionals, including future physicians, have been predicted to respect patients’ rights, however they have not been acquainted with the contents of the bills of rights or what they suggest. Objectives: To assess the awareness among senior medical students at Taif University regarding patients' rights. Subjects and methods: a cross-sectional study was established at the fa
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